Biochemical aspects................................................................................ 102

Explanation.................................................................................................... 101 Evaluation for acceptable daily intake .......................................................... 102 Biochemical aspects ................................................................................ 102 Absorption, distribution and excretion .............................................. 102 Biotransformation .............................................................................. 106 Effects on enzymes and other biochemical parameters .................... 108 Toxicological studies ............................................................................... 109 Acute toxicity ..................................................................................... 109 Short-term studies of toxicity ............................................................ 112 Long-term studies of toxicity and carcinogenicity............................ 121 Genotoxicity ....................................................................................... 126 Reproductive toxicity ......................................................................... 127 Multigeneration studies ................................................................ 127 Developmental toxicity................................................................. 129 Special studies.................................................................................... 130 Neurotoxicity ................................................................................ 130 Immunotoxicity............................................................................. 131 Pharmacological study in mice and rats ...................................... 132 Reversibility of effects on erythrocyte mass parameters in rats.. 132 Test for cytotoxicity in lens epithelial cells in vitro .................... 133 Other toxicological information ................................................... 133 Significance of haematological effects ................................... 133 Significance of lens effects in studies in dogs treated with repeated doses.................................................................... 134 Observations in humans .......................................................................... 136 Comments...................................................................................................... 136 Toxicological evaluation................................................................................ 139 References ..................................................................................................... 141 Appendix ....................................................................................................... 146 Famoxadone and its metabolites in rats and dogs